Targeted Regenerative Aging

Elevated autophagy markers in older tissues often signal stalled cleanup, not better cellular health.

nature.com · 9 sources

Restoring Menin in the hypothalamus reverses mouse brain aging — could Menin-targeted therapy reverse human cognitive decline?

pubmed.ncbi.nlm.nih.gov · 7 sources

Lacosamide’s osteoarthritis benefits point to Nav1.7, but could its pain and cartilage effects instead run through CRMP2-driven pathways?

pubmed.ncbi.nlm.nih.gov · 5 sources

HIIT may uniquely preserve lean muscle during fat loss in healthy older adults, proponents of a recent six‑month trial argue.

unisc.edu.au · 7 sources

P2X7 inhibitors for Alzheimer's and Parkinson's — promising preclinical target stalled by translation.

exa.ai · 8 sources

15-PGDH inhibitors could unlock real knee cartilage regeneration and make many joint replacements avoidable, proponents argue.

med.stanford.edu · 6 sources

Imidazole propionate-producing gut bacteria may be driving accelerated brain aging, some researchers argue.

link.springer.com · 9 sources

Plasma imidazole propionate (ImP) is a contributing cause of Alzheimer’s pathology — or so recent genetic and animal studies suggest.

nature.com · 6 sources

Leucine may protect mitochondrial proteins and raise respiration in stressed tissues.

preview-www.nature.com · 6 sources

Specific BNST neuron subtypes are the hidden switch that turns cannabis into anxiety during stress.

pmc.ncbi.nlm.nih.gov · 9 sources

Increasing hepatic UBE2N activity could block progression from fatty liver to MASH, proponents of the pathway argue.

nrf2.com · 4 sources